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Izposodite Biser Zastarela optimization of led pharmacokinetic Vidnem polju Fundacija Emuliraj

Application of population physiologically based pharmacokinetic modelling to optimize target expression and clearance mechanisms of therapeutic monoclonal antibodies - Reig‐Lopez - 2023 - British Journal of Clinical Pharmacology - Wiley Online Library
Application of population physiologically based pharmacokinetic modelling to optimize target expression and clearance mechanisms of therapeutic monoclonal antibodies - Reig‐Lopez - 2023 - British Journal of Clinical Pharmacology - Wiley Online Library

Pharmaceuticals | Free Full-Text | Optimization of the Pharmacokinetic Profile of [99mTc]Tc-N4-Bombesin Derivatives by Modification of the Pharmacophoric Gln-Trp Sequence
Pharmaceuticals | Free Full-Text | Optimization of the Pharmacokinetic Profile of [99mTc]Tc-N4-Bombesin Derivatives by Modification of the Pharmacophoric Gln-Trp Sequence

Lead Optimization - Creative Biolabs
Lead Optimization - Creative Biolabs

6‐Substituted Pyrrolo[3,4‐c]pyrazoles: An Improved Class of CDK2 Inhibitors - Brasca - 2007 - ChemMedChem - Wiley Online Library
6‐Substituted Pyrrolo[3,4‐c]pyrazoles: An Improved Class of CDK2 Inhibitors - Brasca - 2007 - ChemMedChem - Wiley Online Library

Meloxicam quantification in rabbit plasma by RP-HPLC: optimization and application to pharmacokinetic study | Future Journal of Pharmaceutical Sciences | Full Text
Meloxicam quantification in rabbit plasma by RP-HPLC: optimization and application to pharmacokinetic study | Future Journal of Pharmaceutical Sciences | Full Text

Optimization of human dose prediction by using quantitative and translational pharmacology in drug discovery | Future Medicinal Chemistry
Optimization of human dose prediction by using quantitative and translational pharmacology in drug discovery | Future Medicinal Chemistry

Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades: Trends in Pharmacological Sciences
Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades: Trends in Pharmacological Sciences

Optimizing Pharmacokinetic Property Prediction Based on Integrated Datasets and a Deep Learning Approach | Journal of Chemical Information and Modeling
Optimizing Pharmacokinetic Property Prediction Based on Integrated Datasets and a Deep Learning Approach | Journal of Chemical Information and Modeling

Population Pharmacokinetic Modeling and Dose Optimization of Acetaminophen and its Metabolites Following Intravenous Infusion in Critically ill Adults | SpringerLink
Population Pharmacokinetic Modeling and Dose Optimization of Acetaminophen and its Metabolites Following Intravenous Infusion in Critically ill Adults | SpringerLink

IJERPH | Free Full-Text | The Role of “Physiologically Based Pharmacokinetic Model (PBPK)” New Approach Methodology (NAM) in Pharmaceuticals and Environmental Chemical Risk Assessment
IJERPH | Free Full-Text | The Role of “Physiologically Based Pharmacokinetic Model (PBPK)” New Approach Methodology (NAM) in Pharmaceuticals and Environmental Chemical Risk Assessment

Pharmacokinetic Optimization of Small Molecule Janus Kinase 3 Inhibitors to Target Immune Cells | ACS Pharmacology & Translational Science
Pharmacokinetic Optimization of Small Molecule Janus Kinase 3 Inhibitors to Target Immune Cells | ACS Pharmacology & Translational Science

Pharmacokinetics-guided optimization of QD394 led to QD394-Me having... | Download Scientific Diagram
Pharmacokinetics-guided optimization of QD394 led to QD394-Me having... | Download Scientific Diagram

A Fast Parameter Identification Framework for Personalized Pharmacokinetics | Scientific Reports
A Fast Parameter Identification Framework for Personalized Pharmacokinetics | Scientific Reports

Full article: Analytical methodologies for measuring colistin levels in pharmacokinetic studies
Full article: Analytical methodologies for measuring colistin levels in pharmacokinetic studies

Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties | Journal of Medicinal Chemistry
Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties | Journal of Medicinal Chemistry

Structure-based molecular modeling in SAR analysis and lead optimization - ScienceDirect
Structure-based molecular modeling in SAR analysis and lead optimization - ScienceDirect

Pharmacokinetic–pharmacodynamic modeling of maintenance therapy for childhood acute lymphoblastic leukemia | Scientific Reports
Pharmacokinetic–pharmacodynamic modeling of maintenance therapy for childhood acute lymphoblastic leukemia | Scientific Reports

Diagram of pharmacokinetic/pharmacodynamic (PK/PD) module for... | Download Scientific Diagram
Diagram of pharmacokinetic/pharmacodynamic (PK/PD) module for... | Download Scientific Diagram

Full article: Statistical Sequential Experimentation: Preliminary Mixed Factorial Design, I-Optimal Mixture Design Then Finally Novel Design Space Expansion for Optimization of Tazarotene Cubosomes
Full article: Statistical Sequential Experimentation: Preliminary Mixed Factorial Design, I-Optimal Mixture Design Then Finally Novel Design Space Expansion for Optimization of Tazarotene Cubosomes

Physiologically based pharmacokinetic models for the optimization of antiretroviral therapy: recent progress and future perspective | Future Virology
Physiologically based pharmacokinetic models for the optimization of antiretroviral therapy: recent progress and future perspective | Future Virology

Lead change of a HIF-2α antagonist guided by multiparameter optimization and utilization of an Olp→π*Ar interaction | SpringerLink
Lead change of a HIF-2α antagonist guided by multiparameter optimization and utilization of an Olp→π*Ar interaction | SpringerLink

Microorganisms | Free Full-Text | Optimizing Antimicrobial Drug Dosing in Critically Ill Patients
Microorganisms | Free Full-Text | Optimizing Antimicrobial Drug Dosing in Critically Ill Patients

Pharmacokinetic–pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies | British Journal of Cancer
Pharmacokinetic–pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies | British Journal of Cancer

Optimizing antimicrobial use: challenges, advances and opportunities | Nature Reviews Microbiology
Optimizing antimicrobial use: challenges, advances and opportunities | Nature Reviews Microbiology

Prediction and Optimization of Pharmacokinetic and Toxicity Properties of the Ligand | SpringerLink
Prediction and Optimization of Pharmacokinetic and Toxicity Properties of the Ligand | SpringerLink

Industry Perspective on the Pharmacokinetic and Absorption, Distribution, Metabolism, and Excretion Characterization of Heterobifunctional Protein Degraders | Drug Metabolism & Disposition
Industry Perspective on the Pharmacokinetic and Absorption, Distribution, Metabolism, and Excretion Characterization of Heterobifunctional Protein Degraders | Drug Metabolism & Disposition